Stay away from ibuprofen (Advil, Motrin, Medipren, Nuprin and others). I used to take four 200 mg. tablets twice a day. I did that for over a decade.
So I get a Urinary Tract Infection (UTI) and ignore it for awhile. It backs up from my bladder into my kidneys, which caused the renal failure. But the damage had already been done by the ibuprofen. That's my kidney doctor's (Nephrologist) guess. And that's why I'm slow to get back full function of the kidneys and may never have.
In the hospitl, they said my UTI was a common bug known to them. They put me on antibiotics and it cleared up.
However, I had already damaged my kidneys. I now have Chronic Kidney Disease (CKD) - Moderate. I'm not on dialysis, yet.
If you take ibuprofen, be wary of the dosage. My doctor said 1 tablet is the most that should be taken for a day.
Again, if you "binge" on ibuprofen, consider the risks. I'm not trying to preach down to you; I just don't want any of my pals to end up in my situation. In the tradition of Alcoholics Anonymous, I speak from my "experience, strength, and hope ."